2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase
  5. Ligands for E3 Ligase Isoform

Ligands for E3 Ligase

 

Ligands for E3 Ligase Related Products (123):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122542B
    PPACK TFA 157379-44-7 99.80%
    PPACK TFA is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK TFA binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PPACK TFA also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PPACK TFA can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1.
    PPACK TFA
  • HY-175742
    BMS-986470 3036554-12-5 99.78%
    BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research.
    BMS-986470
  • HY-122542A
    PPACK dihydrochloride 82188-90-7 99.07%
    PPACK dihydrochloride is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK dihydrochloride binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PPACK dihydrochloride also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PPACK dihydrochloride can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1.
    PPACK dihydrochloride
  • HY-W244657
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione 191732-74-8 98.89%
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of the CRBN protein.
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • HY-W037848
    Adamantan-1-ylmethanamine 17768-41-1 99.42%
    Adamantan-1-ylmethanamine (1-Aminomethyladamantane) is a Hyt hydrophobic group. Adamantan-1-ylmethanamine can be used in the synthesis of ZX782 (HY-161972).
    Adamantan-1-ylmethanamine
  • HY-185391
    DCAF1 ligand 2
    DCAF1 ligand 2 (Tert-butyl (2-((2-(1-(4-chlorophenyl)cyclohexyl)-7-(piperazin-1-yl)quinazolin-4-yl)amino)ethyl)carbamate) is a ligand of the E3 connecting enzyme DCAF1. DCAF1 ligand 2 can be used for the synthesis of PROTACs.
    DCAF1 ligand 2
  • HY-W597583
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe 26581-83-9
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand of SIAIS630121-NC (HY-159016). 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. SIAIS630121-NC is a negative control for NAMPT degrader SIAIS630121.
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe
  • HY-181531
    IAP ligand 7
    IAP ligand 7 is an E3 ligase ligand. IAP ligand 7 can be conjugated with TEAD ligand (HY-181595) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .
    IAP ligand 7
  • HY-W013021
    Norbornene 498-66-8 99.95%
    Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895).
    Norbornene
  • HY-W037495
    DCAF15 ligand-1 2098346-67-7 99.32%
    DCAF15 ligand-1 (compound 9) is a ligand for the E3 ligase DCAF15. DCAF15 ligand-1 can be used in the synthesis of IBG1 (HY-153459).
    DCAF15 ligand-1
  • HY-W243404
    3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2304513-76-4 99.95%
    3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research.
    3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • HY-123109A
    (S,S,S)-AHPC-Boc 1797406-74-6
    (S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc (HY-123109), and can be used as an experimental control. (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.
    (S,S,S)-AHPC-Boc
  • HY-W457960
    2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione 2154356-63-3 98.66%
    2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a Thalidomide analog that can be useful in PROTAC research.
    2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione
  • HY-153215
    MEL24 642072-48-8 98.0%
    MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies.
    MEL24
  • HY-175686
    E3 ligase Ligand 67 98.69%
    E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9  μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs.
    E3 ligase Ligand 67
  • HY-148880
    VHLL-BCN 2874203-49-1
    VHLL-BCN is a ligand targeting the VHL E3 ligase, which can be used for the synthesis of PROTAC molecules. As a key component of the copper-free SPAAC-based rapid synthesis platform for transcription factor PROTACs, VHLL-BCN is applicable to cancer-related research.
    VHLL-BCN
  • HY-176036
    MS1262 3070323-06-4 98.61%
    MS1262 is a ligand for the E3 enzyme SPOP substrate GLP and can recruit SPOP. MS1262 can be used to synthesize MS479 (HY-176035).
    MS1262
  • HY-W241635
    Thalidomide acid 1547163-38-1 98.0%
    Thalidomide acid is a Thalidomide analog that can be useful in PROTAC research.
    Thalidomide acid
  • HY-168667
    E3 ligase Ligand 40 98.62%
    E3 Ligase Ligand 40 is an E3 ligase ligand and can be used for the synthesis of PROTAC molecules.
    E3 ligase Ligand 40
  • HY-W076313
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione 959150-64-2 99.88%
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a derivative of Thalidomide with an iodine atom on the benzyl ring
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione